Prevalence of Arterial Stiffness Determined By Cardio-Ankle Vascular Index in Myeloproliferative Neoplasms

Background: Cardiovascular events are the most serious complications for patients with myeloproliferative neoplasms (MPNs). There was limited data regarding to arterial stiffness in these patients. Methods: This a cross-sectional study aiming determine prevalence of that evaluated by cardio-ankle vascular index (CAVI) polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). We defined as mean CAVI 8.0 or more. compared non-MPN cardiovascular risk matching age, sex Thai CV score. Results: A total 80 were enrolled (PV, n=50; ET, n=24; PMF, n=6) median age 63.5 years (IQR 50.9 - 76.1). The majority received aspirin (83.8%) hydroxyurea (81.3%). Seventeen (21.3%) had history thrombosis. MPNs 63.8%, among PV, PMF 70.8%, 60.0%, 66.7%, respectively (p=0.655). After matching, not statistically significant difference when population (65.2% vs 60.9%, P=0.539). Sixty-one (76.3%) high-risk ≥ 60 thrombosis higher those who low-risk ( 8.6 ± 1.2 7.6 1.0, P=0.002). Conclusion: 63.8% comparable risk. Figure 1View largeDownload PPTFigure PPT Close modal